A male body is discovered. He is strangled to death where his face pulverized beyond recognition and fingers burned to a crisp. Kaoru Utsumi (played by Kou Shibasaki) is assigned to the case. The police face great difficulty in cracking the case. Thus, she seeks advice from brilliant physicist Manabu Yukawa (played by Masaharu Fukuyama), aka Detective Galileo.

After analyzing the case, Yukawa suspects that the true genius behind everything is Tetsuya Ishigami (played by Shinichi Tsutsumi), the neighbor of victim's ex-wife. Ishigami happens to be Yukawa's college friend whom he regards as a true mathematics genius.

Elaborate bluffs, false testimonials, loopholes in logic - all begin to appear in Detective Galileo's way as if intentionally placed as a challenge by someone with mathematical brilliance.